Some Groupwise configurations require trusted application keys for 3rd party applications to interface with them.
Below are a couple of links to creating trusted application keys in-house.
http://developer.novell.com/wiki/index.php/Tapp_samples
http://developer.novell.com/wiki/index.php/GroupWise_Trusted_Application_API
If you have a Blackberry Enterprise server, you can also generate a trusted application key using it.
http://www.blackberry.com/btsc/search.do?cmd=displayKC&docType=kc&externalId=KB04571&sliceId=SAL_Public&dialogID=16900851&stateId=1%200%2016904181
For further assistance installing and configuring trusted application keys, please contact Novell directly.